Development pipeline

Indatuximab Ravtansine (BT-062)

Indatuximab Ravtansine (BT-062) is an immune conjugate, consisting of a monoclonal antibody to which a highly effective cytotoxic maytansien derivative (DM4) is coupled. The immune conjugate technology, developed by ImmunoGen, Inc, is used for toxin conjugation. The antibody is directed against the CD138 receptor, which is over-expressed on multiple myeloma cells and on other cells of various types of cancer: solid tumors.

After the conjugate is absorbed into the target cell, DM4 is released and exerts its cytotoxic activity so that the tumor cell is killed. This combination of high effectiveness and specificity with low systemic toxicity distinguishes BT-062 from most therapies currently used in oncology.

Press releases

New data from Biotest's monoclonal antibody-drug-conjug...

03.05.2018,

New data from Biotest's monoclonal antibody-drug-conjugate (ADC) BT-062 in the therapy of solid tumors- Good tolerability and signs of efficacy in phase I/IIa clinical study- Very good effectiveness w ... [More]

ImmunoGen has elected not to exercise its late stage co...

24.03.2017,

ImmunoGen has elected not to exercise its late stage co-development option for the US-Market with Biotest's antibody-drug conjugate (BT-062) - License agreement with ImmunoGen will continueDreieich, 2 ... [More]

Encouraging Efficacy of Indatuximab Ravtansine (BT-062)...

09.12.2014,

Encouraging Efficacy of Indatuximab Ravtansine (BT-062) in Multiple Myeloma in combination with Lenalidomide and Dexamethasone- New data from combination therapy study presented at 56th annual confere ... [More]

Further preclinical studies emphasise the potential of ...

24.10.2014,

Further preclinical studies emphasise the potential of Indatuximab Ravtansine (BT-062) in solid tumours - Antibody-drug conjugate shows high efficacy in an animal model in the treatment of bladder, br ... [More]

Biotest AG initiates clinical study with Indatuximab Ra...

27.03.2014,

Biotest AG initiates clinical study with Indatuximab Ravtansine (BT-062) in solid tumors- First patient treated in phase I/IIa study (no. 989) in patients with triple-negative metastatic breast cancer ... [More]

Clinical Study with Indatuximab Ravtansine (BT-062) in ...

10.12.2013,

Clinical Study with Indatuximab Ravtansine (BT-062) in Multiple Myeloma shows good Tolerability and encouraging Efficacy in Combination with Lenalidomide and Dexamethasone. - Efficacy and tolerability ... [More]

Conference dates

Publications

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ASH 2014 American Society of Hematology (06.12.2014 – 09.12.2014, San Francisco)
PDF, 398.98 kB
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World ADC Weltkongress Antibody Drug Conjugates (26.10.2014 – 29.10.2014, San Diego)
PDF, 834.64 kB
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ASH 2013 American Society of Hematology (06.12.2013 - 10.12.2013, New Orleans)
PDF, 41.61 kB
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ASH 2012 American Society of Hematology, 8. - 11. Dez. 2012, Atlanta (USA)
PDF, 387.58 kB
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Tassone et al.: Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96
[ Link ]

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Ikeda et al.: The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo.Clin Cancer Res. 2009, Jun 15;15(12):4028-37
[ Link ]

Clinical trials

Title

Indication

Status

 
Indatuximab Ravtansine (Study 983) Multiple myeloma Study ongoing

BT062 in Combination With Lenalidomide/Dexamethasone in Patients With Multiple Myeloma

Link clinicaltrials.gov
 
Indatuximab Ravtansine (Study 975) Multiple myeloma Study completed

Safety and Dose Determining Multi-dose Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma

 
Indatuximab Ravtansine (Study 969) Multiple myeloma Study completed

Safety and Dose Determining Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma

 
Indatuximab Ravtansine* (Study 989) Solid tumors Study ongoing

An open-label, twostage Phase I/IIa dose escalation study of BT062 in metastatic triple receptor-negative breast cancer and in metastatic transitional cell carcinoma of the urinary bladder

Link clinicaltrialsregister.eu