Development pipeline

Indatuximab Ravtansine (BT-062)

Indatuximab Ravtansine (BT-062) is an immune conjugate, consisting of a monoclonal antibody to which a highly effective cytotoxic maytansien derivative (DM4) is coupled. The immune conjugate technology, developed by ImmunoGen, Inc, is used for toxin conjugation. The antibody is directed against the CD138 receptor, which is over-expressed on multiple myeloma cells and on other cells of various types of cancer: solid tumors.

After the conjugate is absorbed into the target cell, DM4 is released and exerts its cytotoxic activity so that the tumor cell is killed. This combination of high effectiveness and specificity with low systemic toxicity distinguishes BT-062 from most therapies currently used in oncology.

Press releases

Correction of a release from 11/12/2018 according to Ar...

12.12.2018,

Notification of Major Holdings1. Details of issuer Name: Biotest AG Street: Landsteinerstraße 5 Postal code: 63303 City: DreieichGermany Legal Entity Identifier (LEI): 529900JVX7RPXBLYUD892. Reason fo ... [More]

Release according to Article 40, Section 1 of the WpHG ...

11.12.2018,

Notification of Major Holdings1. Details of issuer Name: Biotest AG Street: Landsteinerstraße 5 Postal code: 63303 City: DreieichGermany Legal Entity Identifier (LEI): 529900JVX7RPXBLYUD892. Reason fo ... [More]

Biotest AG takes next step in developing a new haemophi...

04.12.2018,

Biotest AG takes next step in developing a new haemophilia therapeutic to target patient needs - Biotest exercises its option and receives exclusive rights for haemophilia on the use of Affibody's Alb ... [More]

Hepatect(R) CP and Zutectra(R) show marked efficacy in ...

20.11.2018,

Hepatect(R) CP and Zutectra(R) show marked efficacy in the prevention of HBV reinfection after liver transplantation in long-term study- 371 liver transplanted patients observed over almost seven year ... [More]

Biotest AG acquires ninth plasma collection center in G...

15.11.2018,

Biotest AG acquires ninth plasma collection center in Germany- 100% subsidiary Plasma Service Europe takes over plasma centre in Hanover- In the future, 20 plasma collection centres in Europe to ensur ... [More]

Biotest increases sales in the first nine months of 201...

14.11.2018,

Biotest increases sales in the first nine months of 2018 to EUR 289.6 million- EBIT of EUR 5.1 million despite expenses of EUR 37.8 million for the Biotest Next Level project- Successful qualification ... [More]

Preliminary announcement of the publication of financia...

12.11.2018,

Biotest AG hereby announces that the following financial reports shall be disclosed for the business year 2018: Report: Annual financial report Date of disclosure / German: March 28, 2019 Date of d ... [More]

Preliminary announcement of the publication of quarterl...

12.11.2018,

Biotest AG hereby announces that the following financial reports shall be disclosed for the business year 2019: Report: Quarterly financial report within the 1st half-year (Q1) Date of disclosure / ... [More]

Biotest AG announces successful completion of Mutual Re...

21.08.2018,

Biotest AG announces successful completion of Mutual Recognition Procedure for marketing authorization of Cytotect(R) CP Biotest in twelve European countries- Approval in four additional attractive Eu ... [More]

Cytotect(R) CP prevents transmission of Cytomegalovirus...

15.08.2018,

Cytotect(R) CP prevents transmission of Cytomegalovirus (CMV) to the unborn baby in pregnant women who are infected with CMV for the first time- Transmission of CMV from pregnant women to the foetus i ... [More]

Biotest increases revenues to EUR 200.7 million in the ...

14.08.2018,

Biotest increases revenues to EUR 200.7 million in the first half of 2018- EBIT of EUR 0.6 million despite expenses of EUR 23.7 million for the Biotest Next Level project- Successful qualification of ... [More]

Biotest has closed a transaction to sell all of its pla...

01.08.2018,

Biotest has closed a transaction to sell all of its plasma collection centres in the United States to Grifols- Federal Trade Commission (FTC) approved sale of Biotest US Corporation and its operating ... [More]

Phase IIa study demonstrates favorable safety and toler...

19.07.2018,

Phase IIa study demonstrates favorable safety and tolerability profile for Biotest's monoclonal antibody BT-063 for treatment of systemic lupus erythematosus (SLE)- Study meets primary endpoint for sa ... [More]

Biotest AG opens third plasma collection centre in Czec...

20.06.2018,

Biotest AG opens third plasma collection centre in Czech Republic- 19 plasma collection centres in Europe to ensure long-term plasma supplyDreieich, 20 June 2018. Biotest received an operating permit ... [More]

Release according to Article 40, Section 1 of the WpHG ...

20.06.2018,

Notification of Major Holdings1. Details of issuer Biotest AG Landsteinerstraße 5 63303 Dreieich Germany 2. Reason for notification X Acquisition/disposal of shares with voting rights   Acquisit ... [More]

Large data analysis for DSA after lung transplantation ...

29.05.2018,

Large data analysis for DSA after lung transplantation confirms impressive therapy outcome with Pentaglobin(R)- The development of donor specific antibodies (DSA) can lead to graft rejection and thus ... [More]

Efficacy and safety of Cytotect(R) CP was demonstrated ...

23.05.2018,

Efficacy and safety of Cytotect(R) CP was demonstrated in patients after stem cell transplantation- 78% of "difficult-to-treat" patients responded to Cytotect(R) CP administration- 70% of patients cle ... [More]

Biotest increases revenues in the first quarter 2018 by...

15.05.2018,

Biotest increases revenues in the first quarter 2018 by 34%- Guidance confirmed- Q1 EBIT totalled to EUR -3.0 million after EUR-33.2 million in Q1 2017Dreieich, 15 May 2018. In the first quarter of 20 ... [More]

Biotest AG: Annual general meeting approves payout of d...

15.05.2018,

Biotest AG: Annual general meeting approves payout of dividend- Dividend payout of EUR 0.04 per preference shareDreieich/ Frankfurt a. M., 15 May 2018. At the annual general meeting (AGM) held on 15 M ... [More]

New data from Biotest's monoclonal antibody-drug-conjug...

03.05.2018,

New data from Biotest's monoclonal antibody-drug-conjugate (ADC) BT-062 in the therapy of solid tumors- Good tolerability and signs of efficacy in phase I/IIa clinical study- Very good effectiveness w ... [More]

Conference dates

03.12.2016 – 06.12.2016 | San Diego

Publications

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ASH 2014 American Society of Hematology (06.12.2014 – 09.12.2014, San Francisco)
PDF, 398.98 kB
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World ADC Weltkongress Antibody Drug Conjugates (26.10.2014 – 29.10.2014, San Diego)
PDF, 834.64 kB
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ASH 2013 American Society of Hematology (06.12.2013 - 10.12.2013, New Orleans)
PDF, 41.61 kB
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ASH 2012 American Society of Hematology, 8. - 11. Dez. 2012, Atlanta (USA)
PDF, 387.58 kB
[ Download ]

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Tassone et al.: Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96
[ Link ]

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Ikeda et al.: The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo.Clin Cancer Res. 2009, Jun 15;15(12):4028-37
[ Link ]

Clinical trials

Title

Indication

Status

 
Indatuximab Ravtansine (Study 983) Multiple myeloma Study ongoing

BT062 in Combination With Lenalidomide/Dexamethasone in Patients With Multiple Myeloma

Link clinicaltrials.gov
 
Indatuximab Ravtansine (Study 975) Multiple myeloma Study completed

Safety and Dose Determining Multi-dose Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma

 
Indatuximab Ravtansine (Study 969) Multiple myeloma Study completed

Safety and Dose Determining Study of BT062 in Patients With Relapsed or Refractory Multiple Myeloma

 
Indatuximab Ravtansine* (Study 989) Solid tumors Study ongoing

An open-label, twostage Phase I/IIa dose escalation study of BT062 in metastatic triple receptor-negative breast cancer and in metastatic transitional cell carcinoma of the urinary bladder

Link clinicaltrialsregister.eu