Forschung und Entwicklung

A Novel Coagulation Factor VIII with Reduced Immunogenicity A
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Raising Factor VIII’s Half-Life to the Next Level
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A Next Generation Recombinant Factor VIII for Subcutaneous Hemophilia A Prophylaxis
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Bohländer et al., Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcgRIIA and FcaRI. Front. Immunol. (2021) 12:700429. doi: 10.3389/fimmu.2021.700429.
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Schmidt et al., The Dual Role of a Polyvalent IgM/IgA-Enriched Immunoglobulin Preparation in Activating and Inhibiting the Complement System, Biomedicines (2021) 9, 817.
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Duerr et al.: The novel polyclonal Ab preparation trimodulin attenuates ex vivo endotoxin-induced immune reactions in early hyperinflammation. Innate Immunity 2019, 25(6), 374–388.
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Welte et al., Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). Intensive Care Med. 2018, 44: 438–448.
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Shmygalev et al., IgM-enriched solution BT086 improves host defense capacity and energy store preservation in a rabbit model of endotoxemia. Acta Anaesthesiologica Scandinavica 60 (2016) 502–512. doi: 10.1111/aas.12652.
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EASL European Association for the Study of the Liver 22.-26. April 2015, Vienna (Austria). Zutectra (Zeus)
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Welte et al.: Concept for a study design in patients with severe community-acquired pneumonia: A randomised controlled trial with a novel IgM-enriched immunoglobulin preparation – The CIGMA study. Respiratory Medicine 2015, Volume 109, Issue 6, 758 – 767.
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Schmiedl et al.: Evaluation of pharmacokinetics and safety of the IgM enriched immunoglobulin concentrate BT086 in healthy volunteers – results of a dose-escalating single dose phase I study. Br J Clin Pharmacol 2011, 72:1-46, Abstract 40.
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Schmiedl et al.: Evaluation of pharmacokinetics and safety of the IgM enriched immunoglobulin concentrate BT086 in healthy volunteers - results of a multiple dose phase I study. Br J Clin Pharmacol 2011, 72:1-46. Abstract 43
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Artur Bauhofer et al., Benefits of immunoglobulin substitution in primary and secondary immunodeficiencies: Interim analysis of a prospective, long-term non-interventional study. Int J Clin Pharmacol Ther (2021), 59: 417-427. DOI: 10.5414/CP203952
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Artur Bauhofer et al., Safety monitoring of the intravenous immunoglobulin preparation Intratect in primary and secondary immunodeficiencies: a prospective non-interventional study. Int J Clin Pharmacol Ther (2015), 53: 21-30. DOI: 10.5414/CP202204.
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