Research and development

Publications

In specialist articles, lectures and presentations (for example posters), specialists from Biotest and external scientific and clinical experts report on recent results from research and development.

Here is a list of relevant publications by Biotest.

Haematology

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A Next Generation Recombinant Factor VIII for Subcutaneous Hemophilia A Prophylaxis
PDF, 0.96 MB
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Raising Factor VIII’s Half-Life to the Next Level
PDF, 1.02 MB
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A Novel Coagulation Factor VIII with Reduced Immunogenicity A
PDF, 1.01 MB
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Intensive care medicine

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Bohländer et al., Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcgRIIA and FcaRI. Front. Immunol. (2021) 12:700429. doi: 10.3389/fimmu.2021.700429.
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Schmidt et al., The Dual Role of a Polyvalent IgM/IgA-Enriched Immunoglobulin Preparation in Activating and Inhibiting the Complement System, Biomedicines (2021) 9, 817.
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Duerr et al.: The novel polyclonal Ab preparation trimodulin attenuates ex vivo endotoxin-induced immune reactions in early hyperinflammation. Innate Immunity 2019, 25(6), 374–388.
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Welte et al., Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study). Intensive Care Med. 2018, 44: 438–448.
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Shmygalev et al., IgM-enriched solution BT086 improves host defense capacity and energy store preservation in a rabbit model of endotoxemia. Acta Anaesthesiologica Scandinavica 60 (2016) 502–512. doi: 10.1111/aas.12652.
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EASL European Association for the Study of the Liver 22.-26. April 2015, Vienna (Austria). Zutectra (Zeus)
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Welte et al.: Concept for a study design in patients with severe community-acquired pneumonia: A randomised controlled trial with a novel IgM-enriched immunoglobulin preparation – The CIGMA study. Respiratory Medicine 2015, Volume 109, Issue 6, 758 – 767.
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Schmiedl et al.: Evaluation of pharmacokinetics and safety of the IgM enriched immunoglobulin concentrate BT086 in healthy volunteers – results of a dose-escalating single dose phase I study. Br J Clin Pharmacol 2011, 72:1-46, Abstract 40.
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Schmiedl et al.: Evaluation of pharmacokinetics and safety of the IgM enriched immunoglobulin concentrate BT086 in healthy volunteers - results of a multiple dose phase I study. Br J Clin Pharmacol 2011, 72:1-46. Abstract 43
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Clinical immunology

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Artur Bauhofer et al., Benefits of immunoglobulin substitution in primary and secondary immunodeficiencies: Interim analysis of a prospective, long-term non-interventional study. Int J Clin Pharmacol Ther (2021), 59: 417-427. DOI: 10.5414/CP203952
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Artur Bauhofer et al., Safety monitoring of the intravenous immunoglobulin preparation Intratect in primary and secondary immunodeficiencies: a prospective non-interventional study. Int J Clin Pharmacol Ther (2015), 53: 21-30. DOI: 10.5414/CP202204.
[ Link ]