Biotest AG: Encouraging data of Indatuximab Ravtansine (BT-062) in combination therapy in advanced Multiple Myeloma
News: Biotest AG / Key word(s): Research Update / Encouraging data of Indatuximab Ravtansine (BT-062) in combination therapy in advanced Multiple Myeloma - New data from BT-062 in combination therapy presented at 58th annual conference of the American Society of Hematology - Clinical benefit seen in large majority of patients with advanced multiple myeloma - Very good response achieved in patients who did not respond adequately to prior therapies
In the study, a total of 64 patients were treated with BT-062, used in combination with lenalidomide and dexamethasone (47 patients) or pomalidomide and dexamethasone (17 patients). Enrollment into the study is completed. Patients are treated until progression of multiple myeloma or intolerance. 11 of the 64 heavily pretreated patients enrolled are currently still on treatment, partly for up to 42 months. Currently available efficacy data were evaluated from 43 patients treated with BT-062 in combination with lenalidomide and dexamethasone, who had received at least two complete treatment cycles. 77% of these heavily pretreated patients had an objective response, achieving a partial response or better. Even in 13 patients previously treated with both lenalidomide and bortezomib and who did not respond adequately to the last therapy, an objective response rate of 54% was obtained. This patient population, known to usually have a poor response to treatment, was selected for a treatment with BT-062 in combination with pomalidomide and dexamethasone. Among 14 patients having completed at least 2 treatment cycles, 11 patients achieved a partial or very good partial response, resulting in an objective response rate of 79%. The available data indicates that BT-062 at doses up to 100 mg/m² is well tolerated in both combination regimens. Data from the study suggests that BT-062 in combination with lenalidomide and dexamethasone or pomalidomide and dexamethasone may provide additional treatment options for patients with advanced multiple myeloma. BT-062 in combination with pomalidomide and dexamethasone seems particularly suitable for patients usually known to have a poor outcome. These encouraging data support further investigation in larger clinical studies. Biotest is currently looking for a partner for further development of this promising compound, which is also being investigated in a clinical study in solid tumors. Further information is available on the Biotest website: http://www.biotest.de/ww/en/pub/biotherapeutics/publications.cfm About BT-062 About Biotest IR contact PR contact Biotest AG, Landsteinerstr. 5, 63303 Dreieich, Germany, www.biotest.de Ordinary shares: securities' ID No. 522720; ISIN DE0005227201 Disclaimer 2016-12-06 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. |
Language: | English | |
Company: | Biotest AG | |
Landsteinerstraße 5 | ||
63303 Dreieich | ||
Germany | ||
Phone: | 0 61 03 - 8 01-0 | |
Fax: | 0 61 03 - 8 01-150 | |
E-mail: | investor_relations@biotest.de | |
Internet: | http://www.biotest.de | |
ISIN: | DE0005227235, DE0005227201 | |
WKN: | 522723, 522720 | |
Indices: | SDAX | |
Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange | |
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